Inspired by Atari's 1980 coin-op classic, Centipede: Infestation is an adventure of run-and-gun action and tower-defense styled tactics. From an isometric perspective, the game moves through stereoscopic 3D environments with a dodge-and-fire play mechanic that draws on the arcade original. Pressing ever-forward through dangerous, post-apocalyptic environments -- aptly "infested" with deadly centipedes, spiders, beetles, and other giant, mutant insectoids -- the main character can move and shoot in any direction, à la Ikari Warriors or Heavy Barrel.
The game takes place in more than 40 levels in seven distinct environments. Players take the role of an orphaned teen named Max, who makes his way through the desolate wasteland, sci-fi guns blazing. Along the way he meets a teen girl named Maisy, whose collection of special seeds is the key to bringing plant life back to the planet. Similar to the toadstools in the arcade version of Centipede, plants that spring up from Maisy's seeds can provide temporary cover against the onslaughts. A pair of bug-blasting heroes can battle together through special multiplayer levels. StreetPass features allow two passing Infestation players to trade in-game content. ~ T.J. Deci, All Game Guide